On the day Touma Kamijou and Index see Academy City's space elevator, Endymion in the distance, they meet a Level 0 girl with an amazing singing voice, Arisa Meigo. As the three enjoy their time together after school, magic-user Stiyl Magnus suddenly attacks them. His target: Arisa. Why would a girl from the science side be targeted by someone from the magic side, Touma wonders. In the chaos of Stiyl's attack, he tells Touma, Index and Arisa that she might cause a war between the magic side and the science side.

Touma Kamijou is a student living in Academy City, a highly advanced place in terms of technology. Despite being gauged as a level zero esper (no powers), he possesses on his right hand the Imagine Breaker, an ability that negates any power whatsoever. Touma finds a young girl named Index who is trying to run away from Necessarius, a powerful magic organization that she is member of. Blessed with the skill of memorizing any sort of information, she holds 103,000 forbidden magical books within her head. As science and magic cross paths, Touma must face several dangers amid espers and magicians who appear in the exciting scientific town.

一位瘫痪的退伍军人神秘地重新站了起来并再次行走。

A paralyzed veteran mysteriously stands up and walks again.

一位年轻女子的鬼魂在对活人世界隐形150年后，终于被人看见了。

A ghost of a young woman is finally seen by someone after spending 150 years invisible to the living world.

Techo is a millionaire. Unfortunately, he has a heart disease since he was born. After his parents passed away, he became despaired and lived his life heartlessly. He doesn't care for everyone and anything and likes to risk his life doing dangerous activity. So, everybody sees him thinks that he is a mean and heartless guy. Later, Doctor Sakarin, his personal doctor gets an idea to use art therapy to soothe Techo's mind, so he hires Morin, a jobless artist to teach Techo and inspire him to want to continue his life and wait for a new heart transplant. Eventually, Techo falls in love with Morin